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KMID : 0811720190230050329
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Korean Journal of Physiology & Pharmacology
2019 Volume.23 No. 5 p.329 ~ p.334
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Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models
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Nam Dae-Hwan
Park Jin-Sook
Park Sun-Hyun
Kim Ki-Suk
Baek Eun-Bok
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Abstract
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Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague?Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.
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KEYWORD
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Dipeptidyl peptidase-IV, Gemigliptin, Myocardial ischemia-reperfusion injury, Pressure-volume loop, Spontaneously hypertensive rat
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